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Ralf Paschke Selected Research

Nonautoimmune Hyperthyroidism

12/2023Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
12/2023Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
12/2021Report of a family with three generations of undiagnosed familial nonautoimmune hyperthyroidism.
10/2014A newly discovered TSHR variant (L665F) associated with nonautoimmune hyperthyroidism in an Austrian family induces constitutive TSHR activation by steric repulsion between TM1 and TM7.
3/2011Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.
12/2010Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.
1/2010Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro.
9/2005Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism.

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Ralf Paschke Research Topics

Disease

22Thyroid Neoplasms (Thyroid Cancer)
01/2023 - 11/2002
20Neoplasms (Cancer)
04/2024 - 08/2004
19Thyroid Nodule (Nodule, Thyroid)
10/2020 - 03/2002
19Insulin Resistance
03/2007 - 01/2002
13Obesity
03/2007 - 01/2002
10Goiter
12/2021 - 03/2002
9Papillary Thyroid Cancer
12/2023 - 10/2006
8Nonautoimmune Hyperthyroidism
12/2023 - 09/2005
7Hyperthyroidism
01/2022 - 09/2005
6Adenoma (Adenomas)
11/2016 - 06/2003
5follicular Thyroid cancer
06/2017 - 03/2010
5Follicular Adenocarcinoma
11/2016 - 10/2013
5Type 2 Diabetes Mellitus (MODY)
11/2010 - 03/2003
4Neoplasm Metastasis (Metastasis)
04/2024 - 11/2002
4Atherosclerosis
11/2018 - 04/2004
4Hypothyroidism
05/2018 - 01/2004
4Pituitary Neoplasms (Pituitary Adenoma)
10/2008 - 04/2005
3Endemic Goiter
12/2011 - 11/2003
3Graves Disease (Basedow Disease)
05/2010 - 11/2002
3Thyroid Diseases (Thyroid Disease)
04/2009 - 11/2002
2Hypertension (High Blood Pressure)
11/2018 - 07/2004
2Carcinoma (Carcinomatosis)
01/2015 - 01/2013
2Disease Progression
07/2014 - 09/2003
2Carcinogenesis
05/2014 - 01/2013
2Prolactinoma (Prolactinomas)
11/2010 - 04/2005
2Renal Insufficiency (Renal Failure)
11/2007 - 10/2003
2Hyperplasia
05/2006 - 03/2002
2Multiple Endocrine Neoplasia Type 2a (MEN 2)
05/2006 - 01/2004
2Cardiovascular Diseases (Cardiovascular Disease)
12/2004 - 11/2004
1Dermatitis
10/2022
1Congenital Hypothyroidism (Cretinism)
01/2022
1Neurilemmoma (Schwannoma)
01/2020
1Schwannomatosis
01/2020
1Proteinuria
11/2018
1Chronic Renal Insufficiency
11/2018
1medullary Thyroid cancer
11/2018

Drug/Important Bio-Agent (IBA)

20Thyrotropin Receptors (Thyrotropin Receptor)IBA
12/2023 - 03/2002
14Messenger RNA (mRNA)IBA
01/2020 - 01/2002
12IodineIBA
10/2022 - 03/2002
12Proteins (Proteins, Gene)FDA Link
11/2018 - 01/2002
12AdipokinesIBA
03/2007 - 01/2002
11Hormones (Hormone)IBA
01/2022 - 01/2002
10Insulin (Novolin)FDA Link
07/2006 - 01/2002
8MicroRNAs (MicroRNA)IBA
01/2020 - 07/2011
7Interleukin-6 (Interleukin 6)IBA
07/2006 - 02/2003
7AdiponectinIBA
04/2006 - 01/2002
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2006 - 01/2004
5Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
01/2022 - 07/2002
4RacivirIBA
06/2017 - 01/2013
4ParaffinIBA
06/2017 - 06/2003
4InterleukinsIBA
04/2006 - 02/2004
3Thyroid HormonesIBA
12/2021 - 01/2017
3RNA (Ribonucleic Acid)IBA
01/2020 - 11/2002
3Formaldehyde (Formol)FDA Link
06/2017 - 10/2013
3Biomarkers (Surrogate Marker)IBA
01/2017 - 06/2010
3Thyroxine (Levothyroxine)FDA LinkGeneric
05/2016 - 10/2006
3Calcitonin (Calcitonin, Eel)FDA LinkGeneric
12/2013 - 01/2004
3CalciumIBA
03/2010 - 09/2003
3aryl hydrocarbon receptor-interacting proteinIBA
10/2008 - 05/2006
3ThyroglobulinFDA Link
10/2007 - 11/2002
3Isoproterenol (Isoprenaline)FDA LinkGeneric
07/2006 - 01/2004
3Growth Hormone (Somatotropin)IBA
05/2006 - 04/2005
3Glucose (Dextrose)FDA LinkGeneric
04/2006 - 06/2005
2Mitogen-Activated Protein KinasesIBA
12/2023 - 12/2023
2lenvatinibIBA
11/2018 - 01/2017
2Genetic Markers (Genetic Marker)IBA
05/2016 - 05/2007
2Somatostatin Receptors (Somatostatin Receptor)IBA
05/2010 - 04/2009
2LigandsIBA
01/2010 - 10/2007
2sodium-iodide symporter (sodium iodide symporter)IBA
10/2007 - 02/2004
2Protein Kinase CIBA
10/2007 - 02/2005
2Monocyte Chemoattractant ProteinsIBA
07/2006 - 04/2004
2Dexamethasone (Maxidex)FDA LinkGeneric
07/2006 - 01/2004
2Codon (Codons)IBA
05/2006 - 01/2004
2Octreotide (Sandostatin)FDA LinkGeneric
04/2006 - 08/2004
2Adrenocorticotropic Hormone (ACTH)FDA Link
04/2006 - 08/2004
2Nicotinamide PhosphoribosyltransferaseIBA
06/2005 - 06/2005
2CytokinesIBA
06/2005 - 02/2004
2GlucocorticoidsIBA
12/2004 - 10/2003
1larotrectinibIBA
04/2024
1tyramine-deoxysorbitolIBA
04/2024
1Phosphotransferases (Kinase)IBA
01/2023
1AZD 6244IBA
10/2022
1SteroidsIBA
01/2022
1CatecholaminesIBA
01/2022
1Proto-Oncogene Proteins c-retIBA
01/2022
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2022
1Tyrosine Kinase InhibitorsIBA
01/2021
1Carrier Proteins (Binding Protein)IBA
10/2020
1Guanine NucleotidesIBA
10/2020
1Zoledronic Acid (Zometa)FDA Link
11/2018
1cabozantinibIBA
11/2018
1Colloids (Colloid)IBA
10/2018
1TamoxifenFDA LinkGeneric
05/2018
1Ethanol (Ethyl Alcohol)IBA
05/2016
1Sorafenib (BAY 43-9006)FDA Link
07/2014

Therapy/Procedure

11Therapeutics
01/2017 - 11/2002
8Aftercare (After-Treatment)
10/2016 - 01/2004
4Thyroidectomy
10/2006 - 11/2002
1Precision Medicine
01/2021
1Conservative Treatment
03/2018